Blimp-1, an intrinsic factor that represses HIV-1 proviral transcription in memory CD4+ T cells.

@article{Michaels2015Blimp1AI,
  title={Blimp-1, an intrinsic factor that represses HIV-1 proviral transcription in memory CD4+ T cells.},
  author={Katarzyna Kaczmarek Michaels and Malini Natarajan and Zelda Euler and Galit Alter and Gregory A. Viglianti and Andrew J. Henderson},
  journal={Journal of immunology},
  year={2015},
  volume={194 7},
  pages={3267-74}
}
CD4(+) T cell subsets differentially support HIV-1 replication. For example, quiescent CD4(+) memory T cells are susceptible to HIV-1 infection but do not support robust HIV-1 transcription and have been implicated as the primary reservoir of latent HIV-1. T cell transcription factors that regulate maturation potentially limit HIV-1 transcription and mediate the establishment and maintenance of HIV-1 latency. We report that B lymphocyte-induced maturation protein-1 (Blimp-1), a critical… CONTINUE READING