Bleomycin induces E-selectin expression in cultured umbilical vein endothelial cells by increasing its mRNA levels through activation of NF-kappaB/Rel.

Treatment with bleomycin (BLM) often results in the development of acute lung injury and subsequent fibrosis by mechanisms that are not well understood. It is hypothesized that active oxygen species and proteases generated by inflammatory cells that accumulate in the bronchoalveolus are responsible and that BLM-induced E-selectin expression on the… CONTINUE READING