Bleomycin-induced pulmonary injury in mice deficient in SPARC.

  title={Bleomycin-induced pulmonary injury in mice deficient in SPARC.},
  author={Rashmin C. Savani and Zhaohui Zhou and Evguenia Arguiri and S Z Wang and Diane Vu and Chin C. Howe and Horace M. Delisser},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={279 4},
SPARC (secreted protein, acidic and rich in cysteine) is a component of the matrix that appears to regulate tissue remodeling. There is evidence that it accumulates in the lung in the setting of pulmonary injury and fibrosis, but direct evidence of its involvement is only now emerging. We therefore investigated the development of pulmonary fibrosis induced by bleomycin administered either intratracheally or intraperitoneally in mice deficient in SPARC. Bleomycin (0.15 U/mouse) given… CONTINUE READING
26 Citations
28 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 26 extracted citations


Publications referenced by this paper.
Showing 1-10 of 28 references

The role of hyaluronan/receptor interactions in wound repair

  • RC Savani, DJ Bagli, RE Harrison, EA. Turley
  • 2000
1 Excerpt

Similar Papers

Loading similar papers…