Bleomycin-induced pulmonary fibrosis is independent of eosinophils.

  title={Bleomycin-induced pulmonary fibrosis is independent of eosinophils.},
  author={Hui-jun Hao and Donald A. Cohen and Chester D. Jennings and James S. Bryson and Alan M. Kaplan},
  journal={Journal of leukocyte biology},
  volume={68 4},
Eosinophils have been shown to increase in tissues during many fibrotic conditions and consequently have been suggested to contribute to the development of fibrosis. This study tested the hypothesis that eosinophils are essential in the development of lung fibrosis in mice in response to bleomycin (BLM). Anti-IL-5 antibody was administered intraperitoneally into mice 2 h prior to endotracheal BLM inoculation and thereafter, every other day. Lung eosinophilia was evaluated by measurement of… CONTINUE READING


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