Bleomycin-detectable iron assay for non-transferrin-bound iron in hematologic malignancies.

  title={Bleomycin-detectable iron assay for non-transferrin-bound iron in hematologic malignancies.},
  author={Leni von Bonsdorff and Enni Lindeberg and Leila Sahlstedt and Jari Lehto and Jaakko Parkkinen},
  journal={Clinical chemistry},
  volume={48 2},
BACKGROUND A microwell modification of the bleomycin assay for determining non-transferrin-bound iron (NTBI) was evaluated and compared with a chelation method. METHODS The bleomycin assay reagent and sample volumes were halved, and measurements were done in microwell plates. Samples from patients treated for hematologic malignancies were studied. The chelation method was based on mobilization of NTBI with a chelator and measurement of the ultrafiltered iron-chelator complex. NTBI results… CONTINUE READING
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