Bleomycin: new perspectives on the mechanism of action.

  title={Bleomycin: new perspectives on the mechanism of action.},
  author={Sidney M Hecht},
  journal={Journal of natural products},
  volume={63 1},
The bleomycin group antitumor antibiotics have long been of interest as a consequence of their efficacy in the treatment of certain tumors, not to mention their unique structures and properties in mediating dioxygen activation and sequence selective degradation of DNA. At a chemical level, the structure originally assigned to bleomycin was subsequently reassigned and the new structure has been confirmed by total synthesis. Through the elaboration of structurally modified bleomycin congeners and… CONTINUE READING