Bleeding as presenting symptom of cholestasis.

  title={Bleeding as presenting symptom of cholestasis.},
  author={Johannes N van den Anker and Maarten Sinaasappel},
  journal={Journal of perinatology : official journal of the California Perinatal Association},
  volume={13 4},
Four infants with conjugated hyperbilirubinemia who were brought for treatment primarily because of a hemorrhage are reported. Underlying disorders included extrahepatic biliary atresia, choledochal cysts, and alpha 1-antitrypsin deficiency. Prodromal signs of disturbed coagulation and diminished bile excretion were not recognized. The increased bleeding tendency was probably caused by vitamin K deficiency, resulting from a combination of cholestasis-induced fat malabsorption, absence of… CONTINUE READING