Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis.


A wide variety of toxic chemicals cause blebbing of the plasma membrane in isolated hepatocytes. These alterations in surface structure occur well before cell death. The formation of blebs appears to be directly related to changes in the concentration of extramitochondrial calcium ions. These changes probably reduce the ability of the hepatocyte… (More)


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