Bleb-driven chemotaxis of Dictyostelium cells

@inproceedings{Zatulovskiy2014BlebdrivenCO,
  title={Bleb-driven chemotaxis of Dictyostelium cells},
  author={Evgeny Zatulovskiy and Richard Anthony Tyson and Till Bretschneider and Robert R Kay},
  booktitle={The Journal of cell biology},
  year={2014}
}
Blebs and F-actin-driven pseudopods are alternative ways of extending the leading edge of migrating cells. We show that Dictyostelium cells switch from using predominantly pseudopods to blebs when migrating under agarose overlays of increasing stiffness. Blebs expand faster than pseudopods leaving behind F-actin scars, but are less persistent. Blebbing cells are strongly chemotactic to cyclic-AMP, producing nearly all of their blebs up-gradient. When cells re-orientate to a needle releasing… CONTINUE READING

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