Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation.

  title={Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation.},
  author={Terrence W. Deacon and J H Dinsmore and Lauren C Costantini and Judson Ratliff and O. Isacson},
  journal={Experimental neurology},
  volume={149 1},
In order to assess the potential of embryonic stem cells to undergo neuronal differentiation in vivo, totipotent stem cells from mouse blastocysts (D3 and E14TG2a; previously expanded in the presence of leukemia inhibitory factor) were transplanted, with or without retinoic acid pretreatment, into adult mouse brain, adult lesioned rat brain, and into the mouse kidney capsule. Intracerebral grafts survived in 61% of cyclosporine immunosuppressed rats and 100% of mouse hosts, exhibited variable… CONTINUE READING


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