Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the major translocation cluster region and tetraploid chromosome clones.

@article{Ott1997BlastoidVO,
  title={Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the major translocation cluster region and tetraploid chromosome clones.},
  author={German Ott and Joerg Kalla and M. Michaela Ott and B Schryen and Tiemo Katzenberger and Justus G Mueller and H. K. M{\"u}ller-Hermelink},
  journal={Blood},
  year={1997},
  volume={89 4},
  pages={1421-9}
}
Sixty-four cases of mantle cell (centrocytic) non-Hodgkin's lymphomas have been analyzed for their cytomorphologic features, proliferation indices, bcl-1 rearrangements, p53 expression patterns, and DNA content by both interphase cytogenetic and DNA flow cytometric analyses. According to cytomorphology, three subtypes were recognized: a common, a lymphoblastoid, and a pleomorphic variant of mantle cell lymphoma (MCL). Blastoid MCL subtypes were characterized by distinctly elevated mitotic… CONTINUE READING

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