Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

@article{Stewart1992BlastocystID,
  title={Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor},
  author={Colin L Stewart and Petr Ka{\vs}par and Lisa J. Brunet and Harshida Bhatt and Inder K. Gadi and Frank Koentgen and Susan J. Abbondanzo},
  journal={Nature},
  year={1992},
  volume={359},
  pages={76-79}
}
A CRITICAL point during mammalian pregnancy is the implantation of the blastocyst when the embryo attaches to the wall of the uterus. The autonomously developing preimplantation embryo then becomes dependent on the maternal environment for its continued development. Little is known about the regulation of implantation, except that a complex interaction between peptide and steroid hormones synchronizes the preparation of the uterus for implantation with the development of the embryo. Whether the… 

Preimplantation development of the mammalian embryo and its regulation by growth factors.

TLDR
Uterine expression of LIF at the time of implantation has been described in many species, suggesting that LIF may be of general significance in regulating embryo implantation in mammals.

Leukaemia inhibitory factor and the regulation of pre-implantation development of the mammalian embryo.

  • C. Stewart
  • Biology
    Molecular reproduction and development
  • 1994
TLDR
Data indicate that the maternal environment plays a crucial role in the development and growth of the pre-implantation embryo, by supplying factors that regulate these processes in the embryo.

The Role of Leukemia Inhibitory Factor (LIF) and Other Cytokines in Regulating Implantation in Mammals

  • C. Stewart
  • Biology
    Annals of the New York Academy of Sciences
  • 1994
TLDR
It has long been recognized that the cells that comprise the endometrium of the uterus, the glandular and luminal epithelium, the stroma and hemopoietic cells, undergo a well described series of proliferation and differentiative changes in anticipation of implantation.

Leukemia inhibitory factor can substitute for nidatory estrogen and is essential to inducing a receptive uterus for implantation but is not essential for subsequent embryogenesis.

TLDR
It is shown that uterine expression of LIF is up-regulated by estrogen and LIF can replace nidatory estrogen at inducing both implantation and decidualization in ovariectomized mice.

Basic aspects of implantation.

Factors controlling blastocyst implantation.

Two concepts on the immunological aspect of blastocyst implantation.

  • K. Yoshinaga
  • Medicine, Biology
    The Journal of reproduction and development
  • 2012
TLDR
The first concept I present in this paper is that blastocyst implantation essential factors (BIEFs) have dual functions: one, for structural and functional modification of the endometrium to accommodate the developing embryo and provide nourishment and suitable environment for its development, and the other, for modulation, directly or indirectly, of the maternal immune system to prevent attacks by the maternalimmune system.

Blastocyst-endometrium interaction: intertwining a cytokine network.

TLDR
This review focuses on the actions of interleukin-1, leukemia inhibitory factor,Epidermal growth factor, heparin-binding epidermal Growth factor, and vascular endothelial growth factor and on the network of their interactions leading to early embryo development, peri-implantatory endometrial changes, embryo implantation and trophoblast differentiation.

Blastocyst-endometrium interaction: intertwining a cytokine network

TLDR
This review focuses on the actions of interleukin-1, leukemia inhibitory factor,Epidermal growth factor, heparin-binding epidermal Growth factor, and vascular endothelial growth factor and on the network of their interactions leading to early embryo development, peri-implantatory endometrial changes, embryo implantation and trophoblast differentiation.

Leukemia Inhibitory Factor and Human Embryo Implantation

  • L. Aghajanova
  • Biology, Medicine
    Annals of the New York Academy of Sciences
  • 2004
TLDR
The role of leukemia inhibitory factor (LIF) and its receptors in human embryo implantation and the role of LIF gene mutations in unexplained infertility and implantation failures in IVF patients is not clear yet.
...

References

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Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation.

TLDR
Analysis of LIF expression in pseudopregnant mice and in females undergoing delayed implantation showed that it is under maternal control and that its expression coincides with blastocyst formation and always precedes implantation.

Developmental expression of myeloid leukemia inhibitory factor gene in preimplantation blastocysts and in extraembryonic tissue of mouse embryos

TLDR
The results suggest that this growth factor is synthesized in the extraembryonic part of the embryo and acts on the embryonic tissues during early mouse development.

Role of colony stimulating factor‐1 (CSF‐1) and other lympho‐hematopoietic growth factors in mouse pre‐implantation development

TLDR
Mouse pre‐implantation development appears to be under the control of paracrine and autocrine growth factors, suggesting a partial overlap of the regulatory signals used by the reproductive and lympho‐hematopoietic systems.

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

TLDR
It is demonstrated here that purified, recombinant LIF can substitute for DIA in the maintenance of totipotent ES cell lines that retain the potential to form chimaeric mice.

The genes for leukemia inhibitory factor and interleukin-6 are expressed in mouse blastocysts prior to the onset of hemopoiesis

TLDR
The expression of IL-6 and LIF in blastocysts prior to hemopoiesis suggests that these proteins may regulate the growth and development of trophoblasts or embryonic stem cells.

Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture

TLDR
It is shown that leukaemia inhibitory factor (also known as differentiation inhibitory activity)17,18, a factor secreted by STO fibroblasts, can stimulate proliferation of primordial germ cells in vitro.

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

TLDR
DIA and human interleukin DA/leukaemia inhibitory factor have been identified as related multifunctional regulatory factors with distinct biological activities in both early embryonic and haemopoetic stem cell systems.