Blastic transformation of mantle cell lymphoma: genetic evidence for a clonal link between the two stages of the tumour.

@article{Lszl1999BlasticTO,
  title={Blastic transformation of mantle cell lymphoma: genetic evidence for a clonal link between the two stages of the tumour.},
  author={Ter{\'e}zia L{\'a}szl{\'o} and Andr{\'a}s Matolcsy},
  journal={Histopathology},
  year={1999},
  volume={35 4},
  pages={355-9}
}
AIMS The blastic variant of mantle cell lymphoma (MCL-BV) may develop through histological transformation of mantle cell lymphoma (MCL). However, the clonal link between the tumour cells of MCL and transformed MCL-BV has not been established at the genetic level. To investigate this link longitudinal molecular genetic studies have been performed in two cases of MCL that showed morphological transformation to MCL-BV. METHODS AND RESULTS Polymerase chain reaction (PCR) and nucleotide sequence… CONTINUE READING