Blastic phase of chronic myelogenous leukemia

@article{Esfahani2006BlasticPO,
  title={Blastic phase of chronic myelogenous leukemia},
  author={Merat Karbasian Esfahani and Evelyn L Morris and Janice P. Dutcher and Peter H Wiernik},
  journal={Current Treatment Options in Oncology},
  year={2006},
  volume={7},
  pages={189-199}
}
Opinion statementChronic myelogenous leukemia (CML), also known as chronic myelocytic or chronic myeloid leukemia, is a clonal disorder of hematopoiesis that arises in a hematopoietic stem cell or early progenitor cell. This is characterized by the dysregulated production of mature non-lymphoid cells with normal differentiation. Eventually, in spite of the term chronic, there is progression to acute leukemia, usually of the myeloid variety, which is highly resistant to current therapies… 
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44 Citations

Chronic myelogenous leukemia in the age of imatinib: assessing response, acceleration, and blast phase
TLDR
Problems facing the diagnostic pathologist in this “Age of Imatinib” include accurate diagnosis and determination of CML disease phase prior to therapy, evaluating response to Therapy, and assessing for disease progression on therapy.
Unrelated Allogeneic Stem Cell Transplantation in a Patient with Chronic Myeloid Leukemia in Blast Crisis
TLDR
The following article presents the case of a 49-year-old patient diagnosed with Philadelphia-negative CML in blastic transformation, where after multiple conventional acute leukemia induction chemotherapy regimens an unrelated allogeneic hematopoietic stem cell transplant was performed.
Monocytic crisis of chronic myeloid leukemia in the era of tyrosine kinase inhibitor.
TLDR
A 47-year-old man with Philadelphia chromosome-positive chronic myeloid leukemia (CML) died of pneumonia in March 2012 after being treated with low-dose nilotinib following cytoreduction with MEC (mitoxantrone, etoposide, and cytarabine) chemotherapy.
Megakaryocytic blast crisis at presentation in a pediatric patient with chronic myeloid leukemia.
Case Study Monocytic Crisis of Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitor
A 47-year-old man was diagnosed with Philadelphia chromosome-positive chronic myeloid leukemia (CML) in October 2005. He could not receive treatment with imatinib mesylate due to his economic…
Chronic Myeloid Leukemia with Extramedullary Blast Crisis: Two Unusual Sites with Review of Literature
TLDR
A case of CML who suffered from two discrete episodes of EBC at atypical locations (scalp and paravertebral) within an interval duration of nine months is presented.
Prognostic Factors, Response to Treatment, and Survival in Patients With Chronic Myeloid Leukemia in Blast Phase: A Single-Institution Survey.
Understanding and Monitoring Chronic Myeloid Leukemia Blast Crisis: How to Better Manage Patients
TLDR
Overall, selecting optimal treatment endpoints to predict survival and successful TFR improves the quality of life of patients, and identifying risk factors and developing risk-adapted therapeutic options may contribute to a better outcome for advanced-phase patients.
SYNERGY BETWEEN JAK INHIBITOR RUXOLITINIB AND TYROSINE KINASE INHIBITORS TO OVERCOME DRUG RESISTANCE RELATED TO BONE MARROW STROMA MICROENVIRONMENT IN CHRONIC MYELOID LEUKEMIA
TLDR
The data show that the rational drug combination of TKI and Ruxolitinib may enhance the eradication of primary human Ph+ cells homed in BM stroma niche, and it is proved that JAK inhibitor Ruxolaninib, that inhibits STAT3 phosphorylation (a marker of JAK activity), synergizes with TKIs in the induction of apoptosis in CML primary cells.
Overcoming resistance in chronic myelogenous leukemia
TLDR
This review describes agents which overcome the T315I mutation, as well as native BCR-ABL, via several mechanisms, including increased degradation of BCR, ABL, optimization of direct inhibition of the BCR -ABL kinase, and inhibition of B CR-ABl-mediated cell growth via interruption of the T 315I-mediated transcription, protein synthesis or post-translational modification.
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