Blastic phase of chronic myelogenous leukemia

@article{Esfahani2006BlasticPO,
  title={Blastic phase of chronic myelogenous leukemia},
  author={Merat Karbasian Esfahani and Evelyn L Morris and Janice P. Dutcher and Peter H Wiernik},
  journal={Current Treatment Options in Oncology},
  year={2006},
  volume={7},
  pages={189-199}
}
Opinion statementChronic myelogenous leukemia (CML), also known as chronic myelocytic or chronic myeloid leukemia, is a clonal disorder of hematopoiesis that arises in a hematopoietic stem cell or early progenitor cell. This is characterized by the dysregulated production of mature non-lymphoid cells with normal differentiation. Eventually, in spite of the term chronic, there is progression to acute leukemia, usually of the myeloid variety, which is highly resistant to current therapies… 
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Patients whose accelerated phase reverts to chronic phase after treatment may become candidates for bone marrow transplantation, and nontransplant regimens for accelerated phase that produce long-term benefit are urgently needed.
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