Blast crisis of Ph-positive chronic myeloid leukemia with isochromosome 17q: report of 12 cases and review of the literature.

@article{HernndezBoluda2000BlastCO,
  title={Blast crisis of Ph-positive chronic myeloid leukemia with isochromosome 17q: report of 12 cases and review of the literature.},
  author={Juan-Carlos Hern{\'a}ndez-Boluda and Francisco Cervantes and Dolors Costa and Anna Carri{\'o} and Emili Montserrat},
  journal={Leukemia & lymphoma},
  year={2000},
  volume={38 1-2},
  pages={83-90}
}
Isochromosome 17q [i(17q)] is frequently observed in the blast crisis (BC) of chronic myelogenous leukemia (CML). It has been suggested that this chromosome abnormality is associated with special hematological characteristics of the BC, but the information on this subject is scarce. The clinical, hematological and cytogenetic features of patients with i(17q) were analyzed in a series of 121 patients with BC of Ph-positive CML. Twelve patients (10%) displayed an i(17q), representing the third… CONTINUE READING