Bladder wall penetration of intravesical mitomycin C in dogs.

  title={Bladder wall penetration of intravesical mitomycin C in dogs.},
  author={M. Guillaume Wientjes and James T Dalton and Robert A. Badalament and Joseph R. Drago and Jessie L-S Au},
  journal={Cancer research},
  volume={51 16},
We examined the kinetics of penetration of mitomycin C (MMC) in the dog bladder wall after intravesical instillation of 20 mg/40 ml, a dose used in patients. Bladder tissues were harvested and concentration-depth profiles were established by analysis of thin tissue slices cut parallel to the urothelial surface of the bladder. Tissue concentrations after a dwell time of 5-7 min were similar to those after 30-120 min. In tissues harvested 60 and 75 min after removal of the dose, MMC was not… CONTINUE READING