Bladder tumor contains higher N7-methylguanine levels in DNA than adjacent normal bladder epithelium.

@article{Saad2006BladderTC,
  title={Bladder tumor contains higher N7-methylguanine levels in DNA than adjacent normal bladder epithelium.},
  author={Abir A. Saad and Peter J. O'Connor and Mostafa Mostafa and Nabila E Metwalli and D. P. Cooper and G. P. Margison and Andrew C. Povey},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2006},
  volume={15 4},
  pages={740-3}
}
Schistosoma haematobium-infected patients are more likely to develop bladder cancer and be more exposed to carcinogenic N-nitroso compounds than uninfected patients. As N7-methylguanine is a marker of exposure to methylating agents of this type, we have measured N7-methyldeoxyguanosine 3'-monophosphate (N7-MedGp) by (32)P postlabeling. DNA was isolated from 42 paired normal and tumor tissue of Egyptians with bladder cancer. N7-MedGp was detected in DNA from 93% of the tumors and 74% of the… CONTINUE READING

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Urinary BladderIs associated anatomic site ofBladder Neoplasm
Bladder tumor contains higher N7-methylguanine levels in DNA than adjacent normal bladder epithelium .
Bladder tumor contains higher N7-methylguanine levels in DNA than adjacent normal bladder epithelium .
Bladder tumor contains higher N7-methylguanine levels in DNA than adjacent normal bladder epithelium .
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