Bladder dysfunction in a new mutant mouse model with increased superoxide--lack of nitric oxide?

@article{Soler2010BladderDI,
  title={Bladder dysfunction in a new mutant mouse model with increased superoxide--lack of nitric oxide?},
  author={Roberto Soler and Claudius Fuellhase and Baisong Lu and Colin Edward Bishop and K -E Andersson},
  journal={The Journal of urology},
  year={2010},
  volume={183 2},
  pages={780-5}
}
PURPOSE Nitric oxide mediates urethral smooth muscle relaxation and may also be involved in detrusor activity control. Mice with mutation in the Immp2l gene have high superoxide ion levels and a consequent decrease in the bioavailable amount of nitric oxide. We studied bladder function in this mouse model. MATERIAL AND METHODS Young male mutants at ages 4 to 6 months, old female mutants at age 18 months and healthy WT age matched controls were used. The detrusor contractile response to… CONTINUE READING

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