Bladder carcinogenesis in mice induced by N-butyl-N-(4-hydroxybutyl) nitrosamine and N-ethyl-N-(4-hydroxybutyl)-nitrosamine with reference to the effect of cyclophosphamide.


The carcinogenicities of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) and N-ethyl-N-(4-hydroxybutyl) nitrosamine (EHBN) on the urinary bladder were compared in male BALB/c mice. The effect of cyclophosphamide (CPA) on the carcinogenicities was also investigated. The carcinogenic activity on the bladder mucosa of EHBN was similar to that of BBN, and there… (More)


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