Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.

@article{Figueroa2008BladderCR,
  title={Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.},
  author={Jonine D Figueroa and N{\'u}ria Malats and Montserrat Garc{\'i}a-Closas and Francisco X Real and Debra Silverman and Manolis Kogevinas and Stephen J. Chanock and Robert Welch and Mustafa Dosemeci and Qing Lan and Adonina Tard{\'o}n and Consol Serra and Alfredo Carrato and Reina Garc{\'i}a-Closas and Gemma Casta{\~n}o-Vinyals and Nathaniel Rothman},
  journal={Carcinogenesis},
  year={2008},
  volume={29 10},
  pages={1955-62}
}
Aromatic amines (AAs) and polycyclic aromatic hydrocarbons (PAHs) are carcinogens present in tobacco smoke and functional polymorphisms in NAT2 and GSTM1 metabolizing genes are associated with increased bladder cancer risk. We evaluated whether genetic variation in other candidate metabolizing genes are also associated with risk. Candidates included genes that control the transcription of metabolizing genes [aryl hydrocarbon receptor (AHR), AHRR and aryl hydrocarbon nuclear translocator (ARNT… CONTINUE READING

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