Bladder cancer cell-derived exosomes inhibit tumor cell apoptosis and induce cell proliferation in vitro.

@article{Yang2013BladderCC,
  title={Bladder cancer cell-derived exosomes inhibit tumor cell apoptosis and induce cell proliferation in vitro.},
  author={Lin Yang and Xiao-hou Wu and Danjin Wang and Chunli Luo and Lixue Chen},
  journal={Molecular medicine reports},
  year={2013},
  volume={8 4},
  pages={
          1272-8
        }
}
Exosomes are small membrane vesicles released by a variety of mammalian cells into the extracellular space and are involved in cell‑to‑cell signaling. This study aimed to investigate the effects of bladder cancer cell‑derived exosomes on the regulation of tumor cell viability and apoptosis, as well as the underlying molecular events. Exosomes were purified from the supernatants of human bladder cancer T24 cell cultures. Transmission electron microscopy was used to confirm their morphology and… 
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References

SHOWING 1-10 OF 26 REFERENCES
Gastric cancer exosomes promote tumour cell proliferation through PI3K/Akt and MAPK/ERK activation.
  • J. Qu, X. Qu, +6 authors Y. Liu
  • Biology, Medicine
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2009
Human tumor nanoparticles induce apoptosis of pancreatic cancer cells
TLDR
This study provides the first evidence of an apoptotic function of tumor‐derived nanoparticles on tumor cells, and proposes a new role for nanoparticles, i.e., as signal carriers for interaction between cells, which may have implications in physiopathological situations.
Extracellular, cell-permeable survivin inhibits apoptosis while promoting proliferative and metastatic potential
TLDR
A novel microenvironmental function for survivin in the control of cancer aggressiveness and spread is suggested, and should result in the genesis of additional cancer treatment modalities.
The Genomic and Proteomic Content of Cancer Cell-Derived Exosomes
TLDR
The unique genomic and proteomic contents of exosomes originating from cancer cells as well as their functional effects to promote tumor progression are reviewed.
Malignant effusions and immunogenic tumour-derived exosomes
The Roles of Tumor-Derived Exosomes in Cancer Pathogenesis
TLDR
Tumor-derived exosomes have been viewed as a source of tumor antigens that can be used to induce antitumor immune responses but have been found to possess immunosuppressive properties and are able to facilitate tumor growth, metastasis, and the development of drug resistance.
Purification, characterization and biological significance of tumor-derived exosomes.
TLDR
Data indicate that Tu-exosomes may have physiological functions, cultured with a human breast cancer cell line bound to the cell surface and increased tumor cell proliferation, indicate that it may have biological functions.
Circulating MicroRNA Signatures of Tumor-Derived Exosomes for Early Diagnosis of Non-Small-Cell Lung Cancer.
TLDR
Reports that plasma and serum DNA microsatellite alterations and methylation in patients with early-resected non–small-cell lung cancer (NSCLC) mirrored identical DNA abnormalities in the tumor provided the first hints that detection of these gene abnormalities in serum or plasma could be useful for both cancer diagnosis and detection of recurrence.
Exosome/microvesicle-mediated epigenetic reprogramming of cells.
TLDR
This finding suggests that tumor and stromal cells may talk each other via MVs to establish a favorable tumor niche and to promote tumor growth, invasiveness and progression.
Molecular Characterization of Dendritic Cell-Derived Exosomes
TLDR
DC-derived exosomes accumulate a defined subset of cellular proteins reflecting their endosomal biogenesis and accounting for their biological function, and exosome production is downregulated upon DC maturation, indicating that in vivo,Exosomes are produced by immature DCs in peripheral tissues.
...
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