Blackfoot Disease and Arsenic: A Never-Ending Story

@article{Tseng2005BlackfootDA,
  title={Blackfoot Disease and Arsenic: A Never-Ending Story},
  author={Chin-Hsiao Tseng},
  journal={Journal of Environmental Science and Health, Part C},
  year={2005},
  volume={23},
  pages={55 - 74}
}
  • C. Tseng
  • Published 2005
  • Medicine
  • Journal of Environmental Science and Health, Part C
Abstract Blackfoot disease (BFD) is an endemic peripheral vascular disease confined to the southwestern coast of Taiwan. This article reviews the epidemiology, clinical manifestations and diagnosis, pathology, etiology and pathogenesis of this disease. Sporadic cases of BFD occurred as early as in the early 20th century, and peak incidence was noted between 1956 and 1960, with prevalence rates ranging from 6.51 to 18.85 per 1,000 population in different villages. Typical clinical symptoms and… Expand
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References

SHOWING 1-10 OF 108 REFERENCES
An Overview on Peripheral Vascular Disease in Blackfoot Disease-Hyperendemic Villages in Taiwan
TLDR
The atherogenicity of arsenic could be associated with its effects on hypercoagulability, endothelial injury, smooth muscle cell proliferation, somatic mutation, oxidative stress, and apoptosis, however, its interaction with some trace elements and its association with hypertension and diabetes mellitus could also explain part of its higher risk of developing atherosclerosis. Expand
Blackfoot Disease in Taiwan: A 30-Year Follow-up Study
TLDR
The natural history of blackfoot disease, based on a prospective study of 1,300 patients, is presented and a dose-response relationship between blackfoot dis ease and the duration of water intake was also noted. Expand
A possible pathogenesis for Blackfoot disease--effects of trivalent arsenic (As2O3) on cultured human umbilical vein endothelial cells.
TLDR
It is suggested that arsenic, at both higher and lower concentrations, may damage endothelial cells, and such damage may play an important role in the pathogenesis of BFD. Expand
Abnormal peripheral microcirculation in seemingly normal subjects living in blackfoot-disease-hyperendemic villages in Taiwan.
TLDR
Examination of the possible association between the long-term exposure to artesian well water and the change in microvascular circulation in the absence of peripheral arterial insufficiency showed that those living in the BFD-hyperendemic area had a lower Pb and a slower rate of increase from Pb to Ph. Expand
Dose-response relationship between peripheral vascular disease and ingested inorganic arsenic among residents in blackfoot disease endemic villages in Taiwan.
TLDR
A dose-response relation was observed between the prevalence of peripheral vascular disease and the long-term arsenic exposure in blackfoot disease endemic villages in Taiwan after stopping consumption of artesian well water. Expand
Abnormal current perception thresholds measured by neurometer among residents in blackfoot disease-hyperendemic villages in Taiwan.
TLDR
Normal CPT was observed in seemingly normal subjects without clinical neuropathy in the arseniasis-hyperendemic villages in Taiwan, and stepwise regression analyses consistently showed that residency in BFD villages was significantly associated with higher CPT values after adjusting for age, sex, body height and body weight. Expand
Abnormal Response of Ankle Pressure After Exercise in Seemingly Normal Subjects Living in Blackfoot Disease-Hyperendemic Villages in Taiwan
TLDR
The authors conclude that subclinical arterial insufficiency could be demonstrated in a high percentage of the seemingly normal subjects who had been chronically exposed to arsenic and advocate the exercise test as a screening and monitoring method. Expand
Lipid Profile and Peripheral Vascular Disease in Arseniasis-Hyperendemic Villages in Taiwan
TLDR
The results suggest that the PVD in arse niasis-hyperendemic villages is correlated with ingested inorganic arsenic and not with the lipid profiles. Expand
Chronic Arsenic Intoxication in Asia : Current Perspectives
Chronic arsenic intoxication has been an issue of public health concern in some countries in Asia, such as Taiwan, Mainland China, Bangladesh, India, and Thailand. In Taiwan, an endemic peripheralExpand
Arsenic, geographical isolates, environmental epidemiology, and arteriosclerosis.
TLDR
Few geographical isolates of cardiovascular conditions have been reported, an exception being the recent report of an elevation in the incidence of sudden death in Southeast Asian men, which results from the efforts of environmental epidemiologists being focused predominantly on cancer, pulmonary disease, and birth defects rather than on cardiovascular disease. Expand
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