Black widow spider venom: effect of purified toxin on lipid bilayer membranes.

@article{Finkelstein1976BlackWS,
  title={Black widow spider venom: effect of purified toxin on lipid bilayer membranes.},
  author={Alan Finkelstein and Lee L Rubin and M. C. Tzeng},
  journal={Science},
  year={1976},
  volume={193 4257},
  pages={
          1009-11
        }
}
A purified toxin (the B5 fraction) from black widow spider venom added to the solution on one side of a lipid bilayer membrane interacts irreversibly with the membrane to produce a continuous, linear rise of membrane conductance with time. Conductances greater than 10(-4) reciprocal ohm per square centimeter can eventually be attained without any loss of membrane stability. Membranes treated with toxin are ideally selective for alkali cations over anions and are substantially permeable to… CONTINUE READING

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