Black tea theaflavins inhibit formation of toxic amyloid-β and α-synuclein fibrils.

@article{Grelle2011BlackTT,
  title={Black tea theaflavins inhibit formation of toxic amyloid-β and α-synuclein fibrils.},
  author={Gerlinde Grelle and Albrecht Otto and Mario Lorenz and Ronald F Frank and Erich E. Wanker and Jan Bieschke},
  journal={Biochemistry},
  year={2011},
  volume={50 49},
  pages={10624-36}
}
Causal therapeutic approaches for amyloid diseases such as Alzheimer's and Parkinson's disease targeting toxic amyloid oligomers or fibrils are still emerging. Here, we show that theaflavins (TF1, TF2a, TF2b, and TF3), the main polyphenolic components found in fermented black tea, are potent inhibitors of amyloid-β (Aβ) and α-synuclein (αS) fibrillogenesis. Their mechanism of action was compared to that of two established inhibitors of amyloid formation, (-)-epigallocatechin gallate (EGCG) and… CONTINUE READING
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