Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio.

@article{Bhattacharyya2004BlackTP,
  title={Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio.},
  author={Arindam Bhattacharyya and Debaprasad Mandal and Lakshmishri Lahiry and Gaurisankar Sa and T. Tandra Das},
  journal={Cancer letters},
  year={2004},
  volume={209 2},
  pages={147-54}
}
It is known that cancer is associated with altered immune function. We demonstrated earlier that black tea inhibits tumor growth in a dose-dependent manner. Here, we report that apoptosis was the cause of immunocyte death in Ehrlich's ascites carcinoma (EAC)-bearing mice and anti-tumor dose of black tea restored EAC-induced immunosuppression by inhibiting apoptosis. A search for the molecular mechanism revealed that EAC burden increased the expression of the pro-apoptotic proteins p53 and Bax… CONTINUE READING

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