Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.

@article{Burdette2002BlackC,
  title={Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.},
  author={Joanna E. Burdette and Shao-Nong Chen and Zhi-Zhen Lu and Haiyan Xu and Bethany E. Perez White and Daniel S Fabricant and Jianghua Liu and Harry H. S. Fong and N. R. Farnsworth and Andreas I. Constantinou and Richard B van Breemen and John M Pezzuto and Judy L Bolton},
  journal={Journal of agricultural and food chemistry},
  year={2002},
  volume={50 24},
  pages={7022-8}
}
The roots/rhizomes of Cimicifuga racemosa L. (Nutt.) (black cohosh) have traditionally been used to treat menopausal symptoms through an unknown mechanism of action. In an effort to determine if black cohosh had additional health benefits, methanol extracts were investigated for their potential to scavenge reactive oxygen species and to protect against menadione-induced DNA damage. These extracts effectively scavenged 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals. In addition, the extracts… CONTINUE READING