Black cohosh: just another phytoestrogen?

@article{Viereck2005BlackCJ,
  title={Black cohosh: just another phytoestrogen?},
  author={Volker Viereck and G{\"u}nter Emons and Wolfgang Wuttke},
  journal={Trends in Endocrinology \& Metabolism},
  year={2005},
  volume={16},
  pages={214-221}
}
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Black cohosh (Cimicifuga racemosa) for menopausal symptoms: a systematic review of its efficacy.
Phytoestrogens in Postmenopause: The State of the Art from a Chemical, Pharmacological and Regulatory Perspective
TLDR
The clinical scenario underlying the increased interest on phytoestrogens is outlined, by overviewing the evolution of the evidence on HRT and its main therapeutic goals, and available evidence on their riskbenefit profile is put in a regulatory perspective, in light of the recent regulation on health claims of food supplements.
Effects of herbal preparations on symptom clusters during the menopausal transition
TLDR
Black cohosh mixed with other herbals, Rheum rhaponticum, and French maritime pine bark had significant effects on hot flushes and at least one other symptom and may be a promising alternative treatment to hormonal treatment.
The antiestrogenic effects of black cohosh on BRCA1 and steroid receptors in breast cancer cells
TLDR
Black Cohosh demonstrates substantial anti-cancer properties, and this study may significantly aid in the understanding of the molecular effects of BC on ER-α, PR, and BRCA1 in breast cancer cells.
Ginseng as a Complementary and Alternative Medicine for Postmenopausal Symptoms
Ginseng is a popular herbal medicine that has been used for thousands of years. A number of its components have been isolated and characterized, including ginsenosides, polysaccharides, peptides,…
Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind randomized controlled trial
TLDR
RG could be an attractive herbal dietary supplement for relieving menopausal symptoms and conferring favorable effects on markers of cardiovascular disease in postmenopausal women.
Gene expression profiling reveals effects of Cimicifuga racemosa (L.) NUTT. (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7
TLDR
No estrogenic but antiproliferative and proapoptotic gene expression was shown for black cohosh in MCF-7 cells at the transcriptional level, and the cycloartane glycosides and – for the first time – their aglycons could be identified as an active principle in black cohOSH.
PHARMACOKINETIC DRUG-HERBAL DIETARY SUPPLEMENTS INTERACTIONS CLINICALLY SIGNIFICANT
TLDR
D dosage forms containing standardized herbal extracts, when administered at per label recommended doses, do not pose a risk for clinically relevant herb-drug interactions, however, daily doses exceeding these doses or prolonged treatment may increase prospects for interactions.
EFFECT OF BLACK COHOSH ON BIOCHEMICAL MARKERS OF BONE REMODELING IN POSTMENOPAUSAL WOMEN
Ethanolic extracts of black cohosh (Actaea racemosa) inhibit growth and oestradiol synthesis from oestrone sulphate in breast cancer cells.
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