Black Swans of CRISPR: Stochasticity and Complexity of Genetic Regulation.

@article{Cheong2019BlackSO,
  title={Black Swans of CRISPR: Stochasticity and Complexity of Genetic Regulation.},
  author={Kang Hao Cheong and Jin Ming Koh and Michael C. Jones},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2019},
  pages={
          e1900032
        }
}
Recent waves of controversies surrounding genetic engineering have spilled into popular science in Twitter battles between reputable scientists and their followers. Here, a cautionary perspective on the possible blind spots and risks of CRISPR and related biotechnologies is presented, focusing in particular on the stochastic nature of cellular control processes. 
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References

SHOWING 1-10 OF 13 REFERENCES

The Evolution of Gene-Specific Transcriptional Noise Is Driven by Selection at the Pathway Level

TLDR
It is argued that transcriptional noise constitutes an important component of the phenotype and that variance of expression is a potential target of adaptation, and should therefore be considered together with the mean expression level in functional and evolutionary studies of gene expression.

Multicellular survival as a consequence of Parrondo’s paradox

TLDR
In the face of inevitable aging and death, Nelson and Masel (NM) argue that alternation of ecological populations between nomadic and colonial behaviors has been shown to be critical in allowing survival amidst resource scarcity.

“Memetic Engineering”, Please! Thought, Values and Behaviour Are as Important as Technology!

  • Andrew Moore
  • Art
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2019
TLDR
As I write this editorial, the claim that two Chinese baby girls with CRISPR-Cas-edited genomes have been born is flying around the world, reminding me yet again of the need for unusual contributions from social scientists and philosophers.

Harnessing stochasticity: How do organisms make choices?

TLDR
The solution to this paradox is that organisms can harness stochasticity through which they can generate many possible solutions to environmental challenges and must then employ a comparator to find the solution that fits the challenge.

Time Dependent Stochastic mRNA and Protein Synthesis in Piecewise-deterministic Models of Gene Networks

TLDR
It is found that stochastic fluctuations of the proteome and much less those of the transcriptome can discriminate between various circuit topologies and be applied to multivariate fluctuations of gene expression, generated by gene circuits.

Biological Insights From 108 Schizophrenia-Associated Genetic Loci

TLDR
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.

Chaos An Interdiscip

  • J. Nonlinear Sci 2018,
  • 2018