Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects

  title={Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects},
  author={Krishnapura Srinivasan},
  journal={Critical Reviews in Food Science and Nutrition},
  pages={735 - 748}
  • K. Srinivasan
  • Published 25 October 2007
  • Biology
  • Critical Reviews in Food Science and Nutrition
Black pepper (Piper nigrum) is one of the most widely used among spices. It is valued for its distinct biting quality attributed to the alkaloid, piperine. Black pepper is used not only in human dietaries but also for a variety of other purposes such as medicinal, as a preservative, and in perfumery. Many physiological effects of black pepper, its extracts, or its major active principle, piperine, have been reported in recent decades. Dietary piperine, by favorably stimulating the digestive… 
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Piperine showed a lower hepatoprotective potency than silymarin, but exerted a significant protection against tert-butyl hydroperoxide and carbon tetrachloride hepatotoxicity by reducing both in vitro and in vivo lipid peroxidation, enzymatic leakage of GPT and AP.
Antidiarrhoeal activity of piperine in mice.
P Piperine is an alkaloidal constituent of black and long peppers recently established as a bioavailability enhancer of drugs and other substances and its inhibition of castor oil induced enteropooling suggests its inhibitory effect on prostaglandins.
Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
The data indicate that supplementation with black pepper or the active principle of black pepper, piperine, can reduce high-fat diet induced oxidative stress to the cells.
Stimulation of mouse melanocyte proliferation by Piper nigrum fruit extract and its main alkaloid, piperine.
During a herbal screening programme to find potential repigmenting agents for the treatment of vitiligo, Piper nigrum L. fruit extract was found to possess growth-stimulatory activity towards cultured melanocytes and piperine induced morphological alterations in melan-a cells, with more and longer dendrites observed.
Spice phenolics inhibit human PMNL 5-lipoxygenase.
Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes
The inhibition of lipid peroxidation by curcumin and eugenol was reversed by adding high concentrations of Fe2+.
Immunomodulatory and antitumor activity of Piper longum Linn. and piperine.
Modulatory effect of Piperine on mitochondrial antioxidant system in Benzo(a)pyrene-induced experimental lung carcinogenesis.
Oral supplementation of piperine effectively suppressed lung carcinogenesis in B(a)p induced mice as revealed by the decrease in the extent of mitochondrial lipid peroxidation and concomitant increase in the activities of enzymatic antioxidants.