Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects

@article{Srinivasan2007BlackPA,
  title={Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects},
  author={K. Srinivasan},
  journal={Critical Reviews in Food Science and Nutrition},
  year={2007},
  volume={47},
  pages={735 - 748}
}
  • K. Srinivasan
  • Published 2007
  • Chemistry, Medicine
  • Critical Reviews in Food Science and Nutrition
Black pepper (Piper nigrum) is one of the most widely used among spices. It is valued for its distinct biting quality attributed to the alkaloid, piperine. Black pepper is used not only in human dietaries but also for a variety of other purposes such as medicinal, as a preservative, and in perfumery. Many physiological effects of black pepper, its extracts, or its major active principle, piperine, have been reported in recent decades. Dietary piperine, by favorably stimulating the digestive… Expand
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Piperine-The Bioactive Compound of Black Pepper: From Isolation to Medicinal Formulations.
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A thorough review on conventional and advanced separation techniques for the extraction of piperine from pepper is presented and an outline of the most significant conditions to improve the extraction yield is provided and discussed. Expand
Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders.
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References

SHOWING 1-10 OF 109 REFERENCES
Evaluation of the liver protective potential of piperine, an active principle of black and long peppers.
TLDR
Piperine showed a lower hepatoprotective potency than silymarin, but exerted a significant protection against tert-butyl hydroperoxide and carbon tetrachloride hepatotoxicity by reducing both in vitro and in vivo lipid peroxidation, enzymatic leakage of GPT and AP. Expand
Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs.
TLDR
It appears that the trikatu group of drugs increase bioavailability either by promoting rapid absorption from the gastrointestinal tract, or by protecting the drug from being metabolised/oxidised in its first passage through the liver after being absorbed,or by a combination of these two mechanisms. Expand
Antidiarrhoeal activity of piperine in mice.
TLDR
P Piperine is an alkaloidal constituent of black and long peppers recently established as a bioavailability enhancer of drugs and other substances and its inhibition of castor oil induced enteropooling suggests its inhibitory effect on prostaglandins. Expand
Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
TLDR
The data indicate that supplementation with black pepper or the active principle of black pepper, piperine, can reduce high-fat diet induced oxidative stress to the cells. Expand
Evaluation of the modulatory influence of black pepper (Piper nigrum, L.) on the hepatic detoxication system.
TLDR
The findings revealed a significant and dose-dependent increase in GST and -SH content in the experimental groups except the one maintained on 0.5% black pepper diet for 10 days. Expand
Stimulation of mouse melanocyte proliferation by Piper nigrum fruit extract and its main alkaloid, piperine.
TLDR
During a herbal screening programme to find potential repigmenting agents for the treatment of vitiligo, Piper nigrum L. fruit extract was found to possess growth-stimulatory activity towards cultured melanocytes and piperine induced morphological alterations in melan-a cells, with more and longer dendrites observed. Expand
Effect of black pepper and piperine on bile secretion and composition in rats.
TLDR
The secretion of uronic acids in bile was enhanced by both levels of pepper as also of piperine indicating possible excretion of some of the components of black pepper or of p Piperine as glucuronides. Expand
Spice phenolics inhibit human PMNL 5-lipoxygenase.
TLDR
It is suggested that phenolic compounds present in spices might have physiological role in modulating 5- LO pathway and the synergistic or antagonistic effect of mixtures of spice active principles and spice extracts exerted synergistic effect in inhibiting 5-LO activity. Expand
Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes
TLDR
The inhibition of lipid peroxidation by curcumin and eugenol was reversed by adding high concentrations of Fe2+. Expand
Immunomodulatory and antitumor activity of Piper longum Linn. and piperine.
TLDR
Administration of alcoholic extract of Piper longum as well as piperine could inhibit the solid tumor development in mice induced with DLA cells and increase the life span of mice bearing Ehrlich ascites carcinoma tumor to 37.3 and 58.8%, respectively. Expand
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