Bj-PRO-5a, a natural angiotensin-converting enzyme inhibitor, promotes vasodilatation mediated by both bradykinin B₂and M1 muscarinic acetylcholine receptors.

@article{Morais2011BjPRO5aAN,
  title={Bj-PRO-5a, a natural angiotensin-converting enzyme inhibitor, promotes vasodilatation mediated by both bradykinin B₂and M1 muscarinic acetylcholine receptors.},
  author={K{\'a}tia L. P. Morais and Mirian Akemi Furuie Hayashi and Fernanda Miriani Bruni and Monica Lopes-Ferreira and Antonio Carlos Martins de Camargo and Henning Ulrich and Claudiana Lameu},
  journal={Biochemical pharmacology},
  year={2011},
  volume={81 6},
  pages={736-42}
}
Bradykinin-potentiating peptides (BPPs) or proline-rich oligopeptides (PROs) isolated from the venom glands of Bothrops jararaca (Bj) were the first natural inhibitors of the angiotensin-converting enzyme (ACE) described. Bj-PRO-5a (<EKWAP), a member of this structurally related peptide family, was essential for the development of captopril, the first site-directed ACE inhibitor used for the treatment of human hypertension. Nowadays, more Bj-PROs have been identified with higher ACE inhibition… CONTINUE READING