Bivariate random effects models for meta-analysis of comparative studies with binary outcomes: methods for the absolute risk difference and relative risk.

@article{Chu2012BivariateRE,
  title={Bivariate random effects models for meta-analysis of comparative studies with binary outcomes: methods for the absolute risk difference and relative risk.},
  author={Haitao Chu and Lei Nie and Yong Chen and Yi Huang and Wei Sun},
  journal={Statistical methods in medical research},
  year={2012},
  volume={21 6},
  pages={621-33}
}
Multivariate meta-analysis is increasingly utilised in biomedical research to combine data of multiple comparative clinical studies for evaluating drug efficacy and safety profile. When the probability of the event of interest is rare, or when the individual study sample sizes are small, a substantial proportion of studies may not have any event of interest. Conventional meta-analysis methods either exclude such studies or include them through ad hoc continuality correction by adding an… CONTINUE READING

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