Bivariate familial correlation analysis of quantitative traits by use of estimating equations: application to a familial analysis of the insulin resistance syndrome.

@article{Trgout1999BivariateFC,
  title={Bivariate familial correlation analysis of quantitative traits by use of estimating equations: application to a familial analysis of the insulin resistance syndrome.},
  author={David A Tr{\'e}gou{\"e}t and Bernard Herbeth and Ir{\'e}ne Juhan-Vague and G{\'e}rard Siest and Pierre Ducimeti{\`e}re and Laurence Tiret},
  journal={Genetic epidemiology},
  year={1999},
  volume={16 1},
  pages={
          69-83
        }
}
Familial correlation analysis involving two traits may give a better insight into the etiology of multifactorial syndromes than familial analysis focused on single traits. Significant cross-trait correlations between biological relatives but not between spouses suggest that the two traits share common transmissible factors whereas correlations between spouses additionally suggest the influence of shared lifestyle factors. We apply the Estimating Equations (EE) technique to the estimation of… CONTINUE READING

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