Bivariate analysis of the p53 pathway to evaluate Ad-p53 gene therapy efficacy.

@article{Jacobberger1999BivariateAO,
  title={Bivariate analysis of the p53 pathway to evaluate Ad-p53 gene therapy efficacy.},
  author={James W. Jacobberger and R. Michael Sramkoski and D Zhang and Louis A Zumstein and L D Doerksen and James A. Merritt and Steven A. Wright and Keith E Shults},
  journal={Cytometry},
  year={1999},
  volume={38 5},
  pages={201-13}
}
BACKGROUND Gene therapy of human tumors with adenovirus vectors presents a clinical research challenge and a potential opportunity in cancer therapy. One of the research challenges is that endpoints like tumor reduction, time to recurrence, and survival do not provide information about whether a potential therapeutic infects the targeted cells or whether the transferred gene functions or induces a cellular response. Therefore, a flow cytometric approach was developed for a wildtype, p53… CONTINUE READING