Bivalirudin utilization in cardiac surgery: shifting anticoagulation from indirect to direct thrombin inhibition.

@article{Anand2011BivalirudinUI,
  title={Bivalirudin utilization in cardiac surgery: shifting anticoagulation from indirect to direct thrombin inhibition.},
  author={Sunil Anand and Juan F. Viles-Gonzalez and Sohail K Mahboobi and Paul M. Heerdt},
  journal={Canadian journal of anaesthesia = Journal canadien d'anesthesie},
  year={2011},
  volume={58 3},
  pages={296-311}
}
PURPOSE Bivalirudin use for anticoagulating patients undergoing cardiac surgery, particularly those with or at risk for heparin-induced thrombocytopenia, has expanded over the past several years. The purpose of this review is to provide a summary of the following: the differences between indirect and direct thrombin inhibition, unfractionated heparin's limitations (i.e., heparin-induced thrombocytopenia), bivalirudin's pharmacology, recent cardiac surgery trials comparing bivalirudin and… CONTINUE READING

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