Bivalent ligands with long nanometer-scale flexible linkers.


High-affinity ligands recognizing biomolecules with high specificity are crucial for drug discovery and biomolecule detection. We describe here a simple approach to preparing aptamer-based ligands with enhanced binding affinity. In this approach, two aptamer ligands with suboptimal binding properties are covalently linked with a long flexible linker to… (More)
DOI: 10.1021/bi801630b


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