Bivalent histone modifications in early embryogenesis.

Abstract

Histone modifications influence the interactions of transcriptional regulators with chromatin. Studies in embryos and embryonic stem (ES) cells have uncovered histone modification patterns that are diagnostic for different cell types and developmental stages. For example, bivalent domains consisting of regions of H3 lysine 27 trimethylation (H3K27me3) and… (More)
DOI: 10.1016/j.ceb.2012.03.009

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