Bivalent Regions of Cytosine Methylation and H3K27 Acetylation Suggest an Active Role for DNA Methylation at Enhancers.

@article{Charlet2016BivalentRO,
  title={Bivalent Regions of Cytosine Methylation and H3K27 Acetylation Suggest an Active Role for DNA Methylation at Enhancers.},
  author={Jessica Charlet and Christopher E Duymich and Fides D. Lay and Kamilla Mundbjerg and Karina Dalsgaard S{\o}rensen and Gangning Liang and Peter A. Jones},
  journal={Molecular cell},
  year={2016},
  volume={62 3},
  pages={
          422-431
        }
}
The role of cytosine methylation in the structure and function of enhancers is not well understood. In this study, we investigate the role of DNA methylation at enhancers by comparing the epigenomes of the HCT116 cell line and its highly demethylated derivative, DKO1. Unlike promoters, a portion of regular and super- or stretch enhancers show active H3K27ac marks co-existing with extensive DNA methylation, demonstrating the unexpected presence of bivalent chromatin in both cultured and… CONTINUE READING

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