Bivalent 15 Regularly Associates With the Sex Vesicle in Normal Male Meiosis

@article{MetzlerGuillemain1999Bivalent1R,
  title={Bivalent 15 Regularly Associates With the Sex Vesicle in Normal Male Meiosis},
  author={Catherine Metzler-Guillemain and Cecile Mignon and Danielle Depetris and Marie Roberte Guichaoua and Marie Genevi{\`e}ve Mattei},
  journal={Chromosome Research},
  year={1999},
  volume={7},
  pages={369-378}
}
Using fluorescent in-situ hybridization, we investigated the positioning of different human bivalents at the pachytene stage of normal male meiosis. We showed that, in about 35% of nuclei, the pericentromeric region of bivalent 15 is closely associated with the sex vesicle (SV). This behaviour may be linked to the presence of three domains in the pericentromeric region of chromosome 15: a large imprinted domain, a nucleolar organizing region (NOR), and a heterochromatic block. In order to… CONTINUE READING

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