Bivalence of EGF-like ligands drives the ErbB signaling network.

@article{Tzahar1997BivalenceOE,
  title={Bivalence of EGF-like ligands drives the ErbB signaling network.},
  author={Eldad Tzahar and Ronit Pinkas-Kramarski and James D. Moyer and Leah N. Klapper and Iris Alroy and Gil Levkowitz and Maya Shelly and S Henis and Miriam Eisenstein and Barry Ratzkin and Michael Sela and G. C. Andrews and Yosef Yarden},
  journal={The EMBO journal},
  year={1997},
  volume={16 16},
  pages={4938-50}
}
Signaling by epidermal growth factor (EGF)-like ligands is mediated by an interactive network of four ErbB receptor tyrosine kinases, whose mechanism of ligand-induced dimerization is unknown. We contrasted two existing models: a conformation-driven activation of a receptor-intrinsic dimerization site and a ligand bivalence model. Analysis of a Neu differentiation factor (NDF)-induced heterodimer between ErbB-3 and ErbB-2 favors a bivalence model; the ligand simultaneously binds both ErbB-3 and… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 70 extracted citations

Neuregulins signaling via a glial erbB-2-erbB-4 receptor complex contribute to the neuroendocrine control of mammalian sexual development.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
View 4 Excerpts
Highly Influenced

Erk 5 Participates in Neuregulin Signal Transduction and Is Constitutively Active in Breast Cancer Cells Overexpressing ErbB 2

Azucena Esparı́s-Ogando, Elena Dı́az-Rodrı́guez, +3 authors Atanasio Pandiella
2001
View 17 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 72 references

A subclass of tumorinhibitory monoclonaltransduction

L. N. Klapper, N. Vaisman, +3 authors M. Sela
Cell • 1997
View 5 Excerpts
Highly Influenced

High - resolution solution structure of the EGFcarcinoma cells

N. E. Jacobsen, N. Abadi, +3 authors W. J. Fairbrother
Oncogene • 1996
View 6 Excerpts
Highly Influenced

EGF binding induces

C. Greenfield, I. Hils, +4 authors N. McDonald
1989
View 4 Excerpts
Highly Influenced

Phase II study of weekly intravenous recombinant Biochem

D. Karunagaran, E. Tzahar, N. Liu, D. Wen, Y. Yarden
1996
View 4 Excerpts
Highly Influenced

peptides activate distinct subsets of ErbB receptors and differ in their biological activities

D. Karunagaran, E. Tzahar, R. R. Beerli, X. Chen, D. Graus-Porta
J . Biol . Chem . • 1996
View 4 Excerpts
Highly Influenced

Fusion of sequence elements from nonkinetics of self phosphorylation

P. Moran, I. W. Caras
J . Biol . Chem . • 1991
View 1 Excerpt
Highly Influenced

Similar Papers

Loading similar papers…