Bivalence of EGF-like ligands drives the ErbB signaling network.

  title={Bivalence of EGF-like ligands drives the ErbB signaling network.},
  author={Eldad Tzahar and Ronit Pinkas-Kramarski and James D. Moyer and Leah N. Klapper and Iris Alroy and Gil Levkowitz and Maya Shelly and S Henis and Miriam Eisenstein and Barry Ratzkin and Michael Sela and G. C. Andrews and Yosef Yarden},
  journal={The EMBO journal},
  volume={16 16},
Signaling by epidermal growth factor (EGF)-like ligands is mediated by an interactive network of four ErbB receptor tyrosine kinases, whose mechanism of ligand-induced dimerization is unknown. We contrasted two existing models: a conformation-driven activation of a receptor-intrinsic dimerization site and a ligand bivalence model. Analysis of a Neu differentiation factor (NDF)-induced heterodimer between ErbB-3 and ErbB-2 favors a bivalence model; the ligand simultaneously binds both ErbB-3 and… CONTINUE READING

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