Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes.

@article{Deckmann2014BitterTA,
  title={Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes.},
  author={Klaus Deckmann and Katharina Filipski and Gabriela Krasteva-Christ and Martin Fronius and Mike Althaus and Amir Rafiq and Tamara Papadakis and Liane Renno and Innokentij Jurastow and Lars Wessels and Miriam Wolff and Burkhard Sch{\"u}tz and Elizabeth Weihe and Vladimir Chubanov and Thomas Gudermann and Jochen Klein and Thomas Bschleipfer and Wolfgang Kummer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 22},
  pages={
          8287-92
        }
}
Chemosensory cells in the mucosal surface of the respiratory tract ("brush cells") use the canonical taste transduction cascade to detect potentially hazardous content and trigger local protective and aversive respiratory reflexes on stimulation. So far, the urogenital tract has been considered to lack this cell type. Here we report the presence of a previously unidentified cholinergic, polymodal chemosensory cell in the mammalian urethra, the potential portal of entry for bacteria and harmful… CONTINUE READING

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