Bitter Melon Powder Protects against Obesity-associated Fatty Liver Disease by Improving Colonic Microenvironment in Rats with High-fat Diet-induced Obesity.

  title={Bitter Melon Powder Protects against Obesity-associated Fatty Liver Disease by Improving Colonic Microenvironment in Rats with High-fat Diet-induced Obesity.},
  author={Juan Bai and Yinging Zhu and Ying Dong},
  journal={Biomedical and environmental sciences : BES},
  volume={30 8},
This study explored how bitter melon powder (BMP) alters the colonic microenvironment during the development of obesity-associated fatty liver in rats. We observed that BMP effectively inhibited the body weight gain and lipid accumulation in the liver, ameliorated glucose intolerance, and increased the colon weight after an 8-week treatment compared to that in the high-fat diet (HFD) group. BMP significantly decreased fecal water toxicity towards HT-29 cells, as revealed by the cell counting… Expand
5 Citations
Momordica charantia (bitter melon) modulates adipose tissue inflammasome gene expression and adipose-gut inflammatory cross talk in high-fat diet (HFD)-fed mice.
It is demonstrated that freeze-dried BM juice inhibits recruitment of Mφ into adipose tissue and its polarization to inflammatory phenotype possibly due to reduction of sphingokinase 1 (SPK1) mRNA in HFD-fed mice, and reduction of IL-1β secretion by freeze-dyed BM juice in the adipose tissues of HFD -fed mice is correlated to alleviation of NLRP3 inflammasome components and their downstream signaling targets. Expand
Potential adverse effects of botanical supplementation in high-fat-fed female mice
Data from the current study indicates that dietary supplementation with PMI5011 and bitter melon evokes a divergent, and generally less favorable, set of metabolic responses in female mice compared to effects previously observed in males, underscore the importance of considering sex-related variations in responses to dietary supplementation aimed at combating metabolic syndrome. Expand
Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose
Female mice responded to the high-fat, high-sucrose diet by adaptive increases in fat oxidation energy in muscle and liver, coupled with increased fat storage in white and brown adipose tissue depots, which conferred protection from ectopic lipid accumulation associated with MetS in female mice fed an HFS diet. Expand
Cucurbitane triterpenoids from the fruit of Momordica charantia L. and their anti-hepatic fibrosis and anti-hepatoma activities.
Nine known compounds isolated from the immature fruit of Momordica charantia L. exhibited excellent inhibitory activity against activated t-HSC/Cl-6 cells and cytotoxic activity against Hep3B and HepG2 cell lines with IC50 values, which may potential to be developed as a chemotherapy agent for treatment hepatic fibrosis or carcinoma and protection against both diseases. Expand
The triterpenoids of the bitter gourd (Momordica Charantia) and their pharmacological activities: A review
It is indicated that triterpenoids (triterpenes) which are thought to play a key role in mediating diverse biological effects are likely to be underestimated in bitter gourd. Expand


Response of gut microbiota and inflammatory status to bitter melon (Momordica charantia L.) in high fat diet induced obese rats.
It is demonstrated that BMP ameliorates insulin sensitivity partly via relieving the inflammatory status in the system and in white adipose tissues of obese rats, and is associated with a proportional regulation of specific gut microbiota. Expand
Preventive effects of bitter melon (Momordica charantia) against insulin resistance and diabetes are associated with the inhibition of NF-κB and JNK pathways in high-fat-fed OLETF rats.
  • Soo Jin Yang, J. Choi, +5 authors Cheol-Young Park
  • Medicine
  • The Journal of nutritional biochemistry
  • 2015
The findings of this study indicate that BM exerted preventive effects against insulin resistance and diabetes through the modulation of NF-κB and JNK pathways and may be useful in the prevention of insulin Resistance and diabetes. Expand
Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury.
The role of the gut microbiota and metabolic endotoxemia-induced inflammation in the development of obesity and liver injury is reviewed, with special reference to the intensive care unit setting. Expand
Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice
It is found that changes of gut microbiota induced by an antibiotic treatment reduced metabolic endotoxemia and the cecal content of LPS in both high-fat–fed and ob/ob mice, demonstrating that changes in gut microbiota controls metabolic endotoxinemia, inflammation, and associated disorders by a mechanism that could increase intestinal permeability. Expand
Ameliorative effects of konjac glucomannan on human faecal β-glucuronidase activity, secondary bile acid levels and faecal water toxicity towards Caco-2 cells
It is concluded that supplementation of KGM into a low-fibre diet improved the faecal microbial ecology and metabolites, which may contribute to the reduced toxicity ofFaecal water and precancerous risk factors of human colon cancer. Expand
Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice
It is concluded that specific gut microbiota modulation improves glucose homeostasis, leptin sensitivity, and target enteroendocrine cell activity in obese and diabetic mice. Expand
Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity
Obesity is associated with metabolic alterations related to glucose homeostasis and cardiovascular risk factors. These metabolic alterations are associated with low-grade inflammation thatExpand
Protective effect of lactofermented beetroot juice against aberrant crypt foci formation and genotoxicity of fecal water in rats.
The aim of the study was to investigate the effects of beetroot juice fermented by Lactobacillus brevis 0944 and Lactobacillus paracasei 0920 (FBJ) on carcinogen induction of aberrant crypt fociExpand
Methanolic Extracts of Bitter Melon Inhibit Colon Cancer Stem Cells by Affecting Energy Homeostasis and Autophagy
The results suggest that the extracts of bitter melon can be an effective preventive/therapeutic agent for colon cancer. Expand
A diet high in fat and meat but low in dietary fibre increases the genotoxic potential of 'faecal water'.
The results indicate that diets high in fat and meat but low in dietary fibre increase the genotoxicity of faecal water to colonic cells and may contribute to an enhanced risk of colorectal cancer. Expand