Bitemporal v. high-dose right unilateral electroconvulsive therapy for depression: a systematic review and meta-analysis of randomized controlled trials
@article{Kolshus2016BitemporalVH, title={Bitemporal v. high-dose right unilateral electroconvulsive therapy for depression: a systematic review and meta-analysis of randomized controlled trials}, author={Erik Kolshus and Ana Jelovac and Declan M. McLoughlin}, journal={Psychological Medicine}, year={2016}, volume={47}, pages={518 - 530} }
Background Brief-pulse electroconvulsive therapy (ECT) is the most acutely effective treatment for severe depression though concerns persist about cognitive side-effects. While bitemporal electrode placement is the most commonly used form worldwide, right unilateral ECT causes less cognitive side-effects though historically it has been deemed less effective. Several randomized trials have now compared high-dose (>5× seizure threshold) unilateral ECT with moderate-dose (1.0–2.5× seizure…
84 Citations
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Concerns are raised that these results are misleading at the individual patient level and the important issue of what to do if a patient does not respond sufficiently well to high-dose unilateral, or indeed bitemporal, ECT is highlighted.
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