Bistable properties of a memory-related gene regulatory network

  title={Bistable properties of a memory-related gene regulatory network},
  author={Gonzalo S. Nido and Joanna M. Williams and Lubica Benuskov{\'a}},
  journal={The 2012 International Joint Conference on Neural Networks (IJCNN)},
Long-term potentiation (LTP) is a long-lasting enhancement in signal transmission between two neurons, and represents a widely accepted experimental model for long-term memory processes. Although it is now clear that the maintenance of LTP requires new gene transcription, little is known on the genetic mechanisms underlying these changes. We assume that an LTP-related gene regulatory network has two equilibrium states in terms of gene expression levels which correspond to a pre- and post-LTP… CONTINUE READING


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