Bistable Expression of Virulence Genes in Salmonella Leads to the Formation of an Antibiotic-Tolerant Subpopulation

Abstract

Phenotypic heterogeneity can confer clonal groups of organisms with new functionality. A paradigmatic example is the bistable expression of virulence genes in Salmonella typhimurium, which leads to phenotypically virulent and phenotypically avirulent subpopulations. The two subpopulations have been shown to divide labor during S. typhimurium infections… (More)
DOI: 10.1371/journal.pbio.1001928

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@inproceedings{Arnoldini2014BistableEO, title={Bistable Expression of Virulence Genes in Salmonella Leads to the Formation of an Antibiotic-Tolerant Subpopulation}, author={Markus Arnoldini and Ima Avalos Vizcarra and Rafael Pe{\~n}a-Miller and Nicolas Stocker and M{\'e}d{\'e}ric Diard and Viola Vogel and R. E. Beardmore and Wolf-Dietrich Hardt and Martin Ackermann}, booktitle={PLoS biology}, year={2014} }