Bistability in the JNK cascade

  title={Bistability in the JNK cascade},
  author={C. P. Bagowski and J. Ferrell},
  journal={Current Biology},
  • C. P. Bagowski, J. Ferrell
  • Published 2001
  • Biology, Medicine
  • Current Biology
  • BACKGROUND Important signaling properties, like adaptation, oscillations, and bistability, can emerge at the level of relatively simple systems of signaling proteins. Here, we have examined the quantitative properties of one well-studied signaling system, the JNK cascade. We experimentally assessed the response of JNK to a physiological stimulus (progesterone) and a pathological stress (hyperosmolar sorbitol) in Xenopus laevis oocytes, a cell type that is well-suited to the quantitative… CONTINUE READING
    236 Citations
    Generation of Digital Responses in Stress Sensors*
    • 11
    • PDF
    Digital kinases
    • J. M. López
    • Biology, Medicine
    • Communicative & integrative biology
    • 2010
    • 9
    Autophosphorylation Properties of Inactive and Active JNK2
    • 15
    Basic Properties of the p38 Signaling Pathway in Response to Hyperosmotic Shock
    • 15
    • Highly Influenced
    • PDF
    Competing docking interactions can bring about bistability in the MAPK cascade.
    • 92
    • PDF
    Understanding MAPK Signaling Pathways in Apoptosis
    • 16
    • PDF
    Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades
    • 120
    • Highly Influenced
    • PDF


    Ultrasensitivity in the mitogen-activated protein kinase cascade.
    • C. Huang, J. Ferrell
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1996
    • 1,141
    • PDF
    A model for a bistable biochemical trigger of mitosis.
    • C. Thron
    • Chemistry, Medicine
    • Biophysical chemistry
    • 1996
    • 60
    c-Jun N-terminal Kinase Activation in Xenopus laevis Eggs and Embryos
    • 53
    • PDF
    Signal transduction by the c-Jun N-terminal kinase.
    • R. Davis
    • Chemistry, Medicine
    • Biochemical Society symposium
    • 1999
    • 309
    Frequency selectivity, multistability, and oscillations emerge from models of genetic regulatory systems.
    • 122
    • PDF
    Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
    • 1,242
    Cell cycle regulation of a Xenopus Wee1-like kinase.
    • 310