Bistability in autoimmune diseases.

  title={Bistability in autoimmune diseases.},
  author={Nicolas Rapin and Erik Mosekilde and Ole Lund},
  volume={44 4},
Autoimmune diseases damage host tissue, which, in turn, may trigger a stronger immune response. Systems characterized by such positive feedback loops can display co-existing stable steady states. In a mathematical model of autoimmune disease, one steady state may correspond to the healthy state and another to an autoimmune steady state characterized by widespread tissue damage and immune activation. We show how a triggering event may move the system from the healthy to the autoimmune state and… CONTINUE READING