Bistability analyses of a caspase activation model for receptor-induced apoptosis.

@article{Eissing2004BistabilityAO,
  title={Bistability analyses of a caspase activation model for receptor-induced apoptosis.},
  author={Thomas Eissing and Holger Conzelmann and Ernst Dieter Gilles and Frank Allg{\"o}wer and Eric Bullinger and Peter Scheurich},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 35},
  pages={36892-7}
}
Apoptosis is an important physiological process crucially involved in development and homeostasis of multicellular organisms. Although the major signaling pathways have been unraveled, a detailed mechanistic understanding of the complex underlying network remains elusive. We have translated here the current knowledge of the molecular mechanisms of the death-receptor-activated caspase cascade into a mathematical model. A reduction down to the apoptotic core machinery enables the application of… CONTINUE READING
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