Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.

@article{Guo2007BisphosphonatesTM,
  title={Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.},
  author={Rey-Ting Guo and Rong Cao and Po-Huang Liang and T Ko and T I Chang and Michael P. Hudock and W C Jeng and Cammy K-M Chen and Yonghui Zhang and Yongcheng Song and Chih-Jung Kuo and Fenglin Yin and Eric Oldfield and Andrew H. J. Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 24},
  pages={10022-7}
}
Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS), resulting in decreased prenylation of small GTPases. Here, we show that some bisphosphonates can also inhibit geranylgeranyl diphosphate synthase (GGPPS), as well as undecaprenyl diphosphate synthase (UPPS), a cis-prenyltransferase of interest as a target for antibacterial therapy. Our results on GGPPS (10 structures) show that there are three bisphosphonate-binding… CONTINUE READING

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Here , we show that some bisphosphonates can also inhibit geranylgeranyl diphosphate synthase ( GGPPS ) , as well as undecaprenyl diphosphate synthase ( UPPS ) , a cis - prenyltransferase of interest as a target for antibacterial therapy .
Here , we show that some bisphosphonates can also inhibit geranylgeranyl diphosphate synthase ( GGPPS ) , as well as undecaprenyl diphosphate synthase ( UPPS ) , a cis - prenyltransferase of interest as a target for antibacterial therapy .
Bisphosphonate drugs ( e.g. , Fosamax and Zometa ) are thought to act primarily by inhibiting farnesyl diphosphate synthase ( FPPS ) , resulting in decreased prenylation of small GTPases .
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