Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action.


The mechanisms of action of bisphosphonates (BPs) have been poorly determined. Besides their actions on osteoclasts, these agents exhibit gastrointestinal complications. They have also recently been described as affecting various preparations that express an epithelial Na(+) channel (ENaC). To understand the effects of BP on ion channels and the ENaC in… (More)

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