Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts.

@article{Viereck2002BisphosphonatesPA,
  title={Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts.},
  author={Volker Viereck and Guenter Emons and Vanessa Lauck and K H Frosch and Sabine Blaschke and Carsten Gruendker and Lorenz Christian Hofbauer},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={291 3},
  pages={680-6}
}
Bisphosphonates are potent antiresorptive drugs commonly employed in the treatment of metabolic bone diseases. Despite their frequent use, the mechanisms of bisphosphonates on bone cells have largely remained unclear. Receptor activator of nuclear factor-kappaB ligand (RANKL) is essential for osteoclast formation and activation, whereas osteoprotegerin (OPG) neutralizes RANKL. Various osteotropic drugs have been demonstrated to modulate osteoblastic production of RANKL and OPG. In this study… CONTINUE READING
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